Spapen et al 2001. Soluble fiber reduces the incidence of diarrhea in septic patients receiving total enteral nutrition: a prospective, double-blind, randomized, and controlled trial.

This randomised controlled trial investigated the use of PHGG (partially hydolysed guar gum) in critically ill patients with diarrhoea receiving enteral nutrition. The results illustrated that total enteral nutrition supplemented with soluble fibre is beneficial in reducing the incidence of diarrhoea in tube-fed full-resuscitated and mechanically ventilated septic patients.